![Cells | Free Full-Text | Inhibitory-κB Kinase (IKK) α and Nuclear Factor-κB (NFκB)-Inducing Kinase (NIK) as Anti-Cancer Drug Targets Cells | Free Full-Text | Inhibitory-κB Kinase (IKK) α and Nuclear Factor-κB (NFκB)-Inducing Kinase (NIK) as Anti-Cancer Drug Targets](https://www.mdpi.com/cells/cells-07-00176/article_deploy/html/images/cells-07-00176-g001.png)
Cells | Free Full-Text | Inhibitory-κB Kinase (IKK) α and Nuclear Factor-κB (NFκB)-Inducing Kinase (NIK) as Anti-Cancer Drug Targets
![NHRI researchers report expression of Nik-related kinase in smooth muscle cells attenuates vascular inflammation and intimal hyperplasia – NHRI Communications NHRI researchers report expression of Nik-related kinase in smooth muscle cells attenuates vascular inflammation and intimal hyperplasia – NHRI Communications](https://enews.nhri.edu.tw/en/wp-content/uploads/2020/06/%E5%9C%961-1024x866.jpg)
NHRI researchers report expression of Nik-related kinase in smooth muscle cells attenuates vascular inflammation and intimal hyperplasia – NHRI Communications
NF-κB Inducing Kinase, NIK Mediates Cigarette Smoke/TNFα-Induced Histone Acetylation and Inflammation through Differential Activation of IKKs | PLOS ONE
![Pharmacological inhibition of NF-κB-inducing kinase (NIK) with small molecules for the treatment of human diseases - RSC Medicinal Chemistry (RSC Publishing) DOI:10.1039/D0MD00361A Pharmacological inhibition of NF-κB-inducing kinase (NIK) with small molecules for the treatment of human diseases - RSC Medicinal Chemistry (RSC Publishing) DOI:10.1039/D0MD00361A](https://pubs.rsc.org/image/article/2021/MD/d0md00361a/d0md00361a-f1_hi-res.gif)
Pharmacological inhibition of NF-κB-inducing kinase (NIK) with small molecules for the treatment of human diseases - RSC Medicinal Chemistry (RSC Publishing) DOI:10.1039/D0MD00361A
![Pharmacological inhibition of NF-κB-inducing kinase (NIK) with small molecules for the treatment of human diseases - RSC Medicinal Chemistry (RSC Publishing) DOI:10.1039/D0MD00361A Pharmacological inhibition of NF-κB-inducing kinase (NIK) with small molecules for the treatment of human diseases - RSC Medicinal Chemistry (RSC Publishing) DOI:10.1039/D0MD00361A](https://pubs.rsc.org/image/article/2021/MD/d0md00361a/d0md00361a-s1_hi-res.gif)
Pharmacological inhibition of NF-κB-inducing kinase (NIK) with small molecules for the treatment of human diseases - RSC Medicinal Chemistry (RSC Publishing) DOI:10.1039/D0MD00361A
Pharmacological inhibition of NF-κB-inducing kinase (NIK) with small molecules for the treatment of human diseases - RSC Medicinal Chemistry (RSC Publishing)
![Schematic representation of Nuclear Factor-κB (NF-κB)-inducing kinase... | Download Scientific Diagram Schematic representation of Nuclear Factor-κB (NF-κB)-inducing kinase... | Download Scientific Diagram](https://www.researchgate.net/publication/328472434/figure/fig1/AS:685084017451008@1540348166735/Schematic-representation-of-Nuclear-Factor-kB-NF-kB-inducing-kinase-NIK-inhibitory-kB_Q320.jpg)
Schematic representation of Nuclear Factor-κB (NF-κB)-inducing kinase... | Download Scientific Diagram
![Activation of NF-κB-Inducing Kinase in Islet β Cells Causes β Cell Failure and Diabetes: Molecular Therapy Activation of NF-κB-Inducing Kinase in Islet β Cells Causes β Cell Failure and Diabetes: Molecular Therapy](https://www.cell.com/cms/asset/22fd1d01-96b4-49ea-b564-41d5dec98fed/fx1.jpg)
Activation of NF-κB-Inducing Kinase in Islet β Cells Causes β Cell Failure and Diabetes: Molecular Therapy
Functional interplay between NF-κB-inducing kinase and c-Abl kinases limits response to Aurora inhibitors in multiple myeloma | Haematologica
![Kinases as Novel Therapeutic Targets in Asthma and Chronic Obstructive Pulmonary Disease | Pharmacological Reviews Kinases as Novel Therapeutic Targets in Asthma and Chronic Obstructive Pulmonary Disease | Pharmacological Reviews](https://pharmrev.aspetjournals.org/content/pharmrev/68/3/788/F1.large.jpg)
Kinases as Novel Therapeutic Targets in Asthma and Chronic Obstructive Pulmonary Disease | Pharmacological Reviews
![Catalytic subunits of the phosphatase calcineurin interact with NF-κB-inducing kinase (NIK) and attenuate NIK-dependent gene expression | Scientific Reports Catalytic subunits of the phosphatase calcineurin interact with NF-κB-inducing kinase (NIK) and attenuate NIK-dependent gene expression | Scientific Reports](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fsrep10758/MediaObjects/41598_2015_Article_BFsrep10758_Fig1_HTML.jpg)
Catalytic subunits of the phosphatase calcineurin interact with NF-κB-inducing kinase (NIK) and attenuate NIK-dependent gene expression | Scientific Reports
![Nik‐related kinase is targeted for proteasomal degradation by the chaperone‐dependent ubiquitin ligase CHIP - Naito - 2020 - FEBS Letters - Wiley Online Library Nik‐related kinase is targeted for proteasomal degradation by the chaperone‐dependent ubiquitin ligase CHIP - Naito - 2020 - FEBS Letters - Wiley Online Library](https://febs.onlinelibrary.wiley.com/cms/asset/72f588cf-1b92-4337-88b5-f4163885e5ca/feb213769-fig-0001-m.jpg)
Nik‐related kinase is targeted for proteasomal degradation by the chaperone‐dependent ubiquitin ligase CHIP - Naito - 2020 - FEBS Letters - Wiley Online Library
![NF-κB inducing kinase (NIK) inhibitors: Identification of new scaffolds using virtual screening - ScienceDirect NF-κB inducing kinase (NIK) inhibitors: Identification of new scaffolds using virtual screening - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0960894X10008012-gr1.jpg)
NF-κB inducing kinase (NIK) inhibitors: Identification of new scaffolds using virtual screening - ScienceDirect
![Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K) | Journal of Medicinal Chemistry Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K) | Journal of Medicinal Chemistry](https://pubs.acs.org/cms/10.1021/acs.jmedchem.6b01363/asset/images/large/jm-2016-01363w_0017.jpeg)
Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K) | Journal of Medicinal Chemistry
![Schematic representation of Nuclear Factor-κB (NF-κB)-inducing kinase... | Download Scientific Diagram Schematic representation of Nuclear Factor-κB (NF-κB)-inducing kinase... | Download Scientific Diagram](https://www.researchgate.net/publication/328472434/figure/fig1/AS:685084017451008@1540348166735/Schematic-representation-of-Nuclear-Factor-kB-NF-kB-inducing-kinase-NIK-inhibitory-kB.png)